Administration of the REG1 anticoagulation system

摘要

H:/I/In,,Ievoven/NRPonbi/DCC/KLL/5858223_I.DOC-2/12/2013 An improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host is provided based on weight adjusted or body mass index-adjusted dosing of 5 the components of the system to provide a desired pharmacodynamic response. In addition, a method of reversing activity of the aptamer to a desired extent is provided where an antidote dose is based solely on its relationship to the aptamer dose. i @ 0 L. . . .. .8 %04 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 RB006 Dose (mg/BM I) Page 18 of 24