摘要 |
PROBLEM TO BE SOLVED: To provide a cyclic peptide that inhibits the binding or interaction between p53 protein and MDM2.SOLUTION: The cyclic peptide of the invention has a helix-loop-helix structure formed by A block being a peptide forming α-helix structure positioned at the N-terminal, C block being a peptide forming α-helix structure and positioned at the C-terminal, and B block linking A block and C block by covalent bonds, where the N-terminal amino acid residue of the A block and the C-terminal amino acid residue of the C block are covalently bonded to form a cyclic peptide, the C block has, in its outward potion, four amino acid residues, phenylalanine, tryptophan, leucine or lysine, and leucine, from the N-terminal in this order, and preferably the A block has one or more arginine residues in its outward portion. The cyclic peptide has antitumor action. |