METHOD OF TREATING OR PREVENTING OXIDATIVE STRESS-RELATED DISEASE

摘要

Disclosed is a method of treating or preventing an oxidative stress related disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (1) to the mammal, wherein R1-R4 5 and X1-X3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound. Figure 1A I=o Code X E R R4 m UA H H H H uric acid mUAl H H H Me 9-methyl uric acid mUA2 Me H Me H 1,7-dimethyl mic acid mUA3 Me Me Me H 1,3,7-trimethyl uric acid -H sUA S 0 0 6-monothiouric acid sUA2 S 0 S 6,8-dithiouric acid sUA3 0 S S 2,8-dithiouric acid sUA4 S S S 2,6,8-trithiouric acid