发明名称 |
SMALL MOLECULE CONJUGATES WITH DIMETAL SPECIES FOR PROTEIN INHIBITION |
摘要 |
Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein. |
申请公布号 |
US2014011983(A1) |
申请公布日期 |
2014.01.09 |
申请号 |
US201313916359 |
申请日期 |
2013.06.12 |
申请人 |
WILLIAM MARSH RICE UNIVERSITY |
发明人 |
BALL ZACHARY T.;KUNDU RITUPARNA;POPP BRIAN V.;MADDEN DEAN R.;CUSHING PATRICK R. |
分类号 |
C07K1/107 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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