发明名称 |
METHODS OF USING CEO2 AND TIO2 NANOPARTICLES IN MODULATION OF THE IMMUNE SYSTEM |
摘要 |
<p>Redox-active NPs are disclosed that can potentiate innate immunity and stimulate distinct adaptive responses, producing distinct T cell subset polarization outcomes. Nanomaterials that can alter the cellular redox environment through ROS modulation can impact human immunology. TiO2 nanoparticles potentiate DC maturation, inducing the secretion of IL-12, p70, and IL-1B, while treatment with CeO2 nanoparticles induces IL-10, a hallmark of suppression. When delivered to T cells, the materials direct distinct TH polarization, where TiO2 stimulates largely a TH1 dominated response, whereas CeO2 stimulates a TH2 bias and TReg differentiation.</p> |
申请公布号 |
WO2014008503(A1) |
申请公布日期 |
2014.01.09 |
申请号 |
WO2013US49578 |
申请日期 |
2013.07.08 |
申请人 |
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.;SANOFI PASTEUR VAXDESIGN CORP. |
发明人 |
SCHANEN, BRIAN;WARREN, WILLIAM;SELF, WILLIAM;SEAL, SUDIPTA;DRAKE, DONALD |
分类号 |
A61K33/24;A61K9/14;A61K9/16;A61P37/00 |
主分类号 |
A61K33/24 |
代理机构 |
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