PLGA/CALCIUM CARBONATE COMPOUND MICROSPHERE WITH POROUS SHELL AND PREPARATION METHOD FOR COMPOUND MICROSPHERE

摘要

A PLGA/calcium carbonate compound microsphere with a porous shell and a preparation method for the compound microsphere. The preparation method comprises the following steps of: a, dissolving PLGA in a methylene dichloride organic solvent to obtain a PLGA oil phase; adding calcium carbonate powder to the PLGA oil phase; and stirring and performing ultrasonic treatment to obtain an organic/inorganic uniform mixed liquid; b, dissolving glucolactone in a PVA aqueous solution to obtain an acid PVA aqueous solution; c, dispersing the mixed liquid obtained in the step a into the acid PVA aqueous solution obtained in the step b under a condition of stirring to obtain an oil-in-water single emulsion; d, continuing stirring under a condition of reduced pressure to enable methylene dichloride in an oil phase drop to volatilize to obtain solidified compound microspheres; and e, collecting the microspheres in the step d; washing by using deionized water; and performing freeze drying. According to the method, a pore-forming agent is not introduced, therefore, a porous structure exists on a surface of the prepared compound microsphere, and the compound microsphere is in favor of cell growth.