发明名称 |
MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS |
摘要 |
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species. |
申请公布号 |
EP2681245(A1) |
申请公布日期 |
2014.01.08 |
申请号 |
EP20120751893 |
申请日期 |
2012.03.02 |
申请人 |
ZYMEWORKS, INC. |
发明人 |
DIXIT, SURJIT BHIMARAO;D'ANGELO, IGOR EDMONDO PAOLO;POON, DAVID KAI YUEN |
分类号 |
C07K19/00;C07K14/47;C07K14/485;C07K14/605;C07K14/76;C07K16/00;C07K16/18;C07K16/30 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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