| 发明名称 |
Caged nucleotides |
| 摘要 |
The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the present compounds allows the release of the free nucleotide in vivo or in vitro with precise spatial and temporal control. The compounds are useful for the photolytic generation of free nucleotides in aqueous samples, for example, in the study of calcium mobilization in cells and cell homogenates.
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| 申请公布号 |
US5872243(A) |
申请公布日期 |
1999.02.16 |
| 申请号 |
US19950497183 |
申请日期 |
1995.06.30 |
| 申请人 |
MOLECULAR PROBES, INC.;THE REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
GEE, KYLE R.;LEE, HON CHEUNG;AARHUS, ROBERT;HAUGLAND, RICHARD P.;WALSETH, TIMOTHY F.;GRAEFF, RICHARD M. |
| 分类号 |
C07H19/20;C07H21/02;(IPC1-7):C07H1/00;C07H21/00 |
主分类号 |
C07H19/20 |
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