发明名称 |
OLIGONUCLEOTIDE MODULATORS OF THE TOLL-LIKE RECEPTOR PATHWAY |
摘要 |
Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (PGD) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA compounds, which down regulate or inhibit expression of a Toll like receptor genes. |
申请公布号 |
EP2681315(A1) |
申请公布日期 |
2014.01.08 |
申请号 |
EP20120708475 |
申请日期 |
2012.03.01 |
申请人 |
QUARK PHARMACEUTICALS, INC. |
发明人 |
FEINSTEIN, ELENA;ADAMSKY, SVETLANA;AVKIN-NACHUM, SHARON;KALINSKI, HAGAR;METT, IGOR |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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