发明名称 |
COMPOSITION AND METHODS FOR MODULATION OF VASCULAR STRUCTURE AND/OR FUNCTION |
摘要 |
<p>The present invention relates to compositions comprising semi-crystalline ²-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a ²-1-4 conformation.</p> |
申请公布号 |
EP1365651(B1) |
申请公布日期 |
2014.01.08 |
申请号 |
EP20020740104 |
申请日期 |
2002.02.08 |
申请人 |
MARINE POLYMER TECHNOLOGIES, INC. |
发明人 |
VOURNAKIS, JOHN, N.;FINKIELSZTEIN, SERGIO |
分类号 |
A01N43/04;A61K9/10;A61K9/107;A61K31/70;A61K31/715;A61K31/726;A61P7/04;A61P9/14;A61P43/00;C07B37/00;C07B37/08;C07H1/00;C07H5/04;C07H5/06;C08B37/00;C08B37/08 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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