发明名称 |
CHIMERIC CD27 RECEPTORS FOR REDIRECTING T CELLS TO CD70-POSITIVE MALIGNANCIES |
摘要 |
The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that are CD70-specific are employed. In particular aspects, there are T cells expressing a novel molecule that comprises the full-length CD70 receptor (CD27) fused to the zeta signaling domain of the T-cell receptor complex. Such T cells recognized CD70-positive tumor cells and have cytolytic activity against CD70-positive cancer cells. |
申请公布号 |
KR20140002649(A) |
申请公布日期 |
2014.01.08 |
申请号 |
KR20137013310 |
申请日期 |
2011.10.27 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
GOTTSCHALK STEPHEN M. G;SHAFFER DONALD R.;SPENCER DAVID M. |
分类号 |
C07K14/705;A61K39/00;A61P35/00 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|