Acylthiols and compositions thereof as anti-HIV and anti-retroviral agents
摘要
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
申请公布号
EP1425262(B1)
申请公布日期
2014.01.08
申请号
EP20020756732
申请日期
2002.07.25
申请人
THE GOV. OF USA, AS REPRESENTED BY THE SECRETARY,DEPT. OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
发明人
INMAN, JOHN, K.;GOEL, ATUL;APPELLA, ETTORE;TURPIN, JIM, A.;SCHITO, MARCO