SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSIVANTS

摘要

Compound of formula (I) or salts thereof or solvates thereof: wherein: R1 is hydrogen, C¿1-6?alkyl (optionally substituted by hydroxy or C1-4alkoxy), C1-6alkenyl, C1-6alkynyl, C1-6alkylCO-, formyl, CF3CO-or C1-6alkylSO2-: R?2¿ is hydrogen or up to three substituents selected from halogen, NO¿2?, CN, N3, CF3O-, CF3S-, CF3CO-, CF3SO2, trifluoromethyldiazirinyl, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4)2NCO-, (C1-4alkyl)NHCO- and CONH2; or -NR?5R6¿ where R5 is hydrogen or C¿1-4?alkyl, and R?6¿ is hydrogen, C¿1-4?alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R?2¿ groups together form a carbocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O; the two R groups, the two R3 groups and the two R4 groups are each independently hydrogen, C¿1-6?alkyl, C1-6alkenyl, benzyl, or phenyl, or the two R groups and/or the two R?3¿ groups and/or the two R4 groups together form a C¿3-6?spiroalkyl group, provided that at least one R, R?3 or R4¿ group is other than hydrogen; and X is selected from the group consisting of hydrogen, halogen, cyano, CF¿3?, alkyl and alkoxy; provided that when X is hydrogen, the two R groups are not both hydrogen are indicated to be useful in the treatment and prophylaxis of epilepsy, migraine, and other disorders.