NO synthase inhibitors with trappers of oxygen reactive forms to treat nitric oxide synthase associated diseases

摘要

A pharmaceutical composition comprising as active ingredient, at least one substance inhibiting NO synthase and at least one substance trapping reactive forms of oxygen whereby the effective dosage is relatively less than separate administration of the two substances. The NO synthase inhibitor is an amino acid and more particularly derivatives of L-arginine, ornithine or lysine, or a compound of the family comprising guanidines, isothioureas, nitro- or cyanoaryls, aminopyridines or aminopyrimidines, amidines, indazoles or imidazoles; and the trap of reactive forms of oxygen is ascorbic acid, N-acetylcysteine, b-carotene, the coenzyme Q10, captodative compounds, or a compound of the family comprising phenols, nitrones, indole derivatives, imidazoles, carbazoles. The composition is useful for the treatment of cardiovascular, cerebrovascular disorders, disorders of the CNS or peripheral nervous system such as neurodegnerative diseases, autoimmune and viral diseases.