7'alpha'('xi'-aminoalkyl)estratrienes

摘要

7 alpha -(xi-Aminoalkyl)-oestratriene derivatives of formula (I) and their acid-addition salts wherein: SK = -(CH2)m-NA-CHB-CHD-(CH2)n-SOx-(CH2)3-E; A = H or 1-5C alkyl and B, D = H; or A+B = (CH2)p and D = H; or A+D = (CH2)q and B = H; E = optionally mono- to perfluorinated ethyl; R3 = H, 1-8C hydrocarbyl or COR3'; R3' = H, 1-8C hydrocarbyl or phenyl; R11 = H, halogen or ONO2; R14, R15a, R15b, R16a and R16b = H, or R14+R15a = a bond or a CH2 bridge, or R15b = Me and R15a = H, or R15a and R15b = Me, or R15b+R16b = a CH2 bridge, or R16a or R16b = halogen, or R16a+R16b = methylidene; and the remaining substituents from R14, R15a, R15b, R16a and R16b = H; R17' = H, alkyl, 2-5C alkenyl, 2-5C alkynyl or CF3, or R17'+R14 = CH2CH2 when R17' is in the alpha position; R17" = H or COR17"'; R17"' = H or hydrocarbyl; m = 4-6, n, x = 0-2, p = 2-5, q = 2-4; provided that, if A+B do not form (CH2)p or A+D do not form (CH2)q then R11, R14, R15a, R15a, R16a and R16b are not all H.