发明名称 |
Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells |
摘要 |
The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer. |
申请公布号 |
US8623368(B2) |
申请公布日期 |
2014.01.07 |
申请号 |
US201013503103 |
申请日期 |
2010.10.22 |
申请人 |
LEE JUNG TAE;MOON KYUNG DUK;YOON JI YONG;SUNG BYUNG JE;LEE DONG HEON;LEE DONG EUN;RYU SU YEON;SHIM HYUN BO;KANG KYUNG JAE;HANWHA CHEMICAL CORPORATION |
发明人 |
LEE JUNG TAE;MOON KYUNG DUK;YOON JI YONG;SUNG BYUNG JE;LEE DONG HEON;LEE DONG EUN;RYU SU YEON;SHIM HYUN BO;KANG KYUNG JAE |
分类号 |
A61K39/395;C07K16/28;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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