NOVEL REVAMIPIDE PRODRUGS, PREPARATION METHOD AND USE THEREOF

摘要

The present invention relates to a novel rebamipide precursor, a preparation method thereof, and a use thereof and, more specifically, to a novel rebamipide precursor, a preparation method thereof, and a pharmaceutical composition containing thereof as an active ingredient. The novel rebamipide precursor of the present invention has 25 times more of a body absorption rate when compared to the rebamipide, and is capable of replacing the rebamipide as a prevention and treatment agent for stomach ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, and obesity. [Reference numerals] (AA) Prodrug area ratio; (BB) Rebamipide area ratio