发明名称 Processes of making and using pharmaceutical formulations of antineoplastic agents
摘要 In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.
申请公布号 US8623868(B2) 申请公布日期 2014.01.07
申请号 US201113290251 申请日期 2011.11.07
申请人 UGWU SYDNEY;RADHAKRISHNAN VINAY;IHNAT PETER M.;WITCHEY-LAKSHMANAN LENORE C.;MERCK SHARP & DOHME CORP. 发明人 UGWU SYDNEY;RADHAKRISHNAN VINAY;IHNAT PETER M.;WITCHEY-LAKSHMANAN LENORE C.
分类号 A61K31/53;C07D487/04;A61K9/19;A61K31/395;A61K31/40;A61K31/415;A61K31/4188;A61K31/522;A61K31/66;A61K31/704;A61K47/04;A61K47/10;A61K47/12;A61K47/18;A61K47/26;A61K47/34;A61K47/36;A61K47/38;A61K47/40;A61P35/00 主分类号 A61K31/53
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