发明名称 |
Anti-ICAM-1 single domain antibody and uses thereof |
摘要 |
Anti-ICAM-1 VHH single-domain antibodies (sdAbs) are generated by immunizing a llama with recombinant ICAM-1. These antibodies are linked to an imaging moiety for in vivo or ex vivo imaging of ICAM-1-related pathological conditions including atherosclerotic plaques. The antibodies may also be linked to a therapeutic agent to specifically target and treat ICAM-1-related pathological conditions. |
申请公布号 |
US8623369(B2) |
申请公布日期 |
2014.01.07 |
申请号 |
US201113643412 |
申请日期 |
2011.04.27 |
申请人 |
ABULROB ABEDELNASSER;ARBABI-GHAHROUDI MEHDI;STANIMIROVIC DANICA;NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
ABULROB ABEDELNASSER;ARBABI-GHAHROUDI MEHDI;STANIMIROVIC DANICA |
分类号 |
A61K39/395;C07K16/28;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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