发明名称 Pegylering af rekombinante blodkoagulationsfaktorer i nærvær af bundne antistoffer
摘要 The present invention relates to a proteinaceous construct comprising a blood coagulation factor, e.g., Factor VIII (FVIII), being bound to at least one water soluble polymer, including a poly(alkylene oxide) such as polyethylene glycol (PEG). Further the present invention relates to methods of preparing PEGylated blood coagulation factor, e.g., FVIII, in the presence of bound antibodies. The invention also relates to methods for prolonging the in vivo-half-life of blood coagulation factor, e.g., FVIII, in the blood of a mammal having a bleeding disorder associated with functional defects or deficiencies of blood coagulation factor, e.g., FVIII.
申请公布号 DK2349341(T3) 申请公布日期 2014.01.06
申请号 DK20090748174T 申请日期 2009.10.14
申请人 BAXTER INTERNATIONAL INC;BAXTER HEALTHCARE SA 发明人 MITTERER, ARTUR;GRANINGER, MICHAEL;HASSLACHER, MEINHARD
分类号 A61K47/48 主分类号 A61K47/48
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