发明名称 |
ANTIBODY |
摘要 |
<p>Provided is an antibody that is purified using temperature-responsive affinity chromatography and acid treated. Specifically, impurities and antibody aggregates are removed from a solution containing antibody monomers, antibody aggregates, and impurities using temperature-responsive affinity chromatography, solution that has been subjected to temperature-responsive affinity chromatography is acid treated, and antibodies are obtained in which the ratio of the concentration of antibody aggregates (a multimer that is at least dimeric) to the concentration of antibody monomers is reduced in comparison to before the acid treatment.</p> |
申请公布号 |
WO2014003142(A1) |
申请公布日期 |
2014.01.03 |
申请号 |
WO2013JP67720 |
申请日期 |
2013.06.27 |
申请人 |
ASAHI KASEI MEDICAL CO., LTD. |
发明人 |
KOGUMA, ICHIRO;OKUYAMA, KAZUO |
分类号 |
C07K16/00;A61K39/395;C07K1/22;G01N30/00;G01N30/26;G01N30/88 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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