发明名称 |
MASS-SPECTRAL METHOD FOR SELECTION, AND DE-SELECTION, OF CANCER PATIENTS FOR TREATMENT WITH IMMUNE RESPONSE GENERATING THERAPIES |
摘要 |
A method and system for predicting in advance of treatment whether a cancer patient is likely, or not likely, to obtain benefit from administration of a yeast-based immune response generating therapy, which may be yeast-based immunotherapy for mutated Ras-based cancer, alone or in combination with another anti-cancer therapy. The method uses mass spectrometry of a blood-derived patient sample and a computer configured as a classifier using a naming set of class-labeled spectra from other cancer patients that either benefitted or did not benefit from an immune response generating therapy alone or in combination with another anti-cancer therapy. Also disclosed are methods of treatment of a cancer patient, comprising administering a yeast-based immune response generating therapy, which may be yeast-based immunotherapy for mutated Ras-based cancer, to a patient selected by a test in accordance with predictive mass spectral methods disclosed herein, in which the class label for the spectra indicates the patient is likely to benefit from the yeast-based immunotherapy. |
申请公布号 |
CA2878044(A1) |
申请公布日期 |
2014.01.03 |
申请号 |
CA20132878044 |
申请日期 |
2013.03.15 |
申请人 |
BIODESIX, INC.;GLOBEIMMUNE, INC. |
发明人 |
RODER, JOANNA;RODER, HEINRICH |
分类号 |
G01N33/68;G01N33/574 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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