发明名称 |
SELECTIVE CARTILAGE THERAPY |
摘要 |
The present invention relates to compositions, methods and kits for delivery of an IGF-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (HB) comprising SEQ ID NO: 1 or SEQ ID NO: 2. Other aspects relate to use of a HB-IGF-1 fusion proteins in methods to deliver IGF-1 to the cartilage for the treatment of a cartilage related disease and disorder in a subject. |
申请公布号 |
WO2014004467(A1) |
申请公布日期 |
2014.01.03 |
申请号 |
WO2013US47556 |
申请日期 |
2013.06.25 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;IPSEN/BIOMEASURE INCORPORATED |
发明人 |
LEE, RICHARD T.;PATWARI, PARTH;LOFFREDO, FRANCESCO;PANCOAST, JAMES;DONG, ZHENG XIN;VANNELLI, TODD |
分类号 |
C07K14/475;A61K38/00;A61P19/04;C07K14/65;C12N15/62 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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