发明名称 |
ANTI-ENDOGLIN ANTIBODIES AND KNOCKIN MICE EXPRESSING NOVEL HUMAN/MOUSE CHIMERIC ENDOGLIN |
摘要 |
Provided are compositions and methods that relate to prophylaxis and therapy of angiogenesis associated disease and includes novel knockin mice which express novel human/mouse chimeric endoglin, vectors for use in making such mice, and murine embryonic stem cells comprising the novel human/mouse transgene. Also provided are anti-human endoglin monoclonal antibodies (mAbs) which can be used as antiangiogenic agents for prophylaxis or therapy of human tumor angiogenesis and human angiogenesis-associated diseases having excessive vascularization. The mAbs do not cross react with murine endoglin. Also provides are methods for using the anti-human endoglin mAbs for prophylaxis or therapy of human tumor angiogenesis and for angiogenesis-associated diseases having excessive vascularization. |
申请公布号 |
EP2678034(A2) |
申请公布日期 |
2014.01.01 |
申请号 |
EP20120777072 |
申请日期 |
2012.02.23 |
申请人 |
HEALTH RESEARCH, INC. |
发明人 |
SEON, BEN, K.;TOI, HIROFUMI |
分类号 |
A61K39/395;A61K47/48;A61K48/00;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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