| 摘要 |
The Invention relates to the pharmaceutical composition intended to treat the vascular, traumatic, toxic, hypoxic, and autoimmune genesis central and peripheral nervous system diseases, in the form of the solution for parenteral, intranasal, and subconjunctival administration; wherein the active ingredient is the 0.01 to 2.0 mg/ml biologically active protein-polypeptide complex with the tissue-specific reparative effect on the nervous tissue, obtained from the mid first third to mid last third gestational age livestock embryonic brain tissue, which complex contains the negatively charged faintly acid neutral proteins and polypeptides relating to the growth factor, differentiation factor, signaling molecules, that determine its biologic and pharmacologic activity, with the 5 to 200 kDa molecular masses, wherein at least 80% of the total protein mass has the 10 to 120 kDa molecular mass, and characterized by a peak at the 274-284 nm wave length in the UV-visible spectrum and bands in the pI 4.2 to 8.4 range at isoelectric focusing in a 5% polyacrylamide gel, and which complex contains a pharmaceutically acceptable diluent. |
