Vascular model, method for its manufacture and application

摘要

The vascular model comprises a microchannel (10) that is perfusable by fluid and is present in a form of a hollow structure (11) having a wall thickness of 0.1-1000 mu m, a concave inner surface with a cross-section that is circular in part and a pore (12) having a diameter of 1 nm to 100 mu m, a chamber (20) that is perfusable by one of a same and a different fluid and surrounds the microchannel over an entire length and width of the microchannel, and a connector (31, 32) configured to receive or discharge the fluid. The chamber adjoins the microchannel. The vascular model comprises a microchannel (10) that is perfusable by fluid and is present in a form of a hollow structure (11) having a wall thickness of 0.1-1000 mu m, a concave inner surface with a cross-section that is circular in part and a pore (12) having a diameter of 1 nm to 100 mu m, a chamber (20) that is perfusable by one of a same and a different fluid and surrounds the microchannel over an entire length and width of the microchannel, and a connector (31, 32) configured to receive or discharge the fluid. The chamber adjoins the microchannel. The microchannel: has a width of 0.01 mu m to 10 mm, a depth of 0.01 mu m to 10 mm and a radius of curvature of 0.01-10000 mu m; is in a straight form; and includes a division into two branches. The hollow structure is formed of: a film made of a thermoplastic polymer; an ion track membrane; and a nonwoven or a phase separation membrane. The chamber comprises two chambers. A second chamber surrounds a first chamber that surrounds the microchannel in such a way that a nested structure is formed. Each of the two chambers surrounds only sub regions of the microchannel. The vascular model further comprises a cover that closes the microchannel in a rigid or releasable manner. Independent claims are included for: (1) a method for producing a vascular model; and (2) a method for culturing tubular tissue structures.