| 发明名称 |
TRICYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES |
| 摘要 |
The present invention provides inhibitors of kinases, specifically I.kappa.B kinases, JAK1, JAK2, JAK3 and TYK2, comprising formula I (see formula I) The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinases activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-.kappa.B-mediated diseases. |
| 申请公布号 |
CA2630562(C) |
申请公布日期 |
2013.12.31 |
| 申请号 |
CA20062630562 |
申请日期 |
2006.11.17 |
| 申请人 |
MERCK & CO., INC.;MERCK FROSST CANADA LTD. |
发明人 |
TRUCHON, JEAN-FRANCOIS;LACHANCE, NICOLAS;LAU, CHEUK K.;LEBLANC, YVES;MELLON, CHRISTOPHE;ROY, PATRICK;ISABEL, ELISE;OTTE, RYAN D.;YOUNG, JONATHAN R. |
| 分类号 |
C07D471/04;A61K31/4355;A61K31/4365;A61K31/437;A61P35/00;C07D491/107;C07D495/04 |
主分类号 |
C07D471/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
