发明名称 |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
摘要 |
A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFalpha including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. |
申请公布号 |
US8617894(B2) |
申请公布日期 |
2013.12.31 |
申请号 |
US201313845291 |
申请日期 |
2013.03.18 |
申请人 |
CENTOCOR ORTHO BIOTECH INC.;JANSSEN BIOTECH, INC. |
发明人 |
JACOBS STEVEN;O'NEIL KARYN |
分类号 |
A61K38/16;C07K16/00;C12N15/00;C12P21/08 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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