Thieno-pyridine derivatives as mek inhibitors and uses thereof for the preparation of medicaments for the treatment and/or prevention of inflammatory, autoimmune, cardiovascular, proliferative, nociceptive and oncological conditions

摘要

A series of thieno[2,3-b]pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.