A NOVEL CONJUGATE OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) WITH POLYETHYLENE GLYCOL

摘要

The present invention relates to pharmaceuticals and medicine, namely, to new physiologically active conjugates of granulocyte colony-stimulating factor (G-CSF) with the general formula (I)where n is integers from 681 to 1000; m is an integer ≥4; NαH-G-CSF is granulocyte colony-stimulating factor. The invention also relates to medicines containing the claimed conjugate of formula (I), pharmaceutical compositions, the use of conjugate of formula (I) for drugs and medicines having the activity with granulocyte colony stimulating factor as an active ingredient, a method of preventing and/or treating neutropenia, the container that comprises pharmaceutical composition or a medicine and a kit.