发明名称 |
IMIDAZO BICYCLIC IMMINIUM COMPOUNDS AS ANTITUMOR AGENTS |
摘要 |
Imidazobicycles having a quaternary nitrogen, i.e. imminium salts, are disclosed. Examples include derivatives of 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepinium and 2,3-dihydroimidazo[2,1-b]thiazolium salts. The compounds are inhibitors of the Hedgehog pathway and therefore useful as antitumor agents and as probes of the function of Hedgehog-dependent systems. |
申请公布号 |
CA2877473(A1) |
申请公布日期 |
2013.12.27 |
申请号 |
CA20132877473 |
申请日期 |
2013.06.19 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
CHEN, JAMES;KATO, TOMOYO SAKATA;ONDRUS, ALISON EVELYNN |
分类号 |
C07D487/04;A61K31/437;A61P35/00;C07D471/04 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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