| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: present invention is related to compounds of formula I , which are inhibitors of p38 kinase and may be used in medicine, where A represents N or N+O-; R1 represents phenyl or heterocyclyl; R2 represents heterocyclyl; R3 represents H, carbocyclic radical, aryl or heterocyclyl; R4 represents H, Ra, halogen, -ORa', -CN, -CONRa'Ra', -NRa'Ra', -NRa'CORa' or -NRa'CO2Ra; R5 may be connected to any of nitrogens of pyrazole ring of compound in formula I and represents H, alkyl, alkenyl, carbocyclic radical, aryl or heterocyclyl; Ra independently represents alkyl, carbocyclic radical, aryl or heterocyclyl; each Ra' independently represents H or Ra. ^ EFFECT: preparation of new biologically active compounds. ^ 41 cl, 299 ex, 15 tbl |
