发明名称 |
PRODRUG DERIVATIVES OF (E)-N-METHYL-N-((3-METHYLBENZOFURAN-2-YL)METHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-3-YL)ACRYLAMIDE |
摘要 |
In part, the present disclosure is directed to derivatives of (E)-N-methy1-N-(( 3-methylta 1,8-naphthyndin-3-y1)acrylamide compounds with significant solubility, solid state stability and bioavailability profiles. Said compounds have been found to be effective inhibitors of bacterial fatty acid metabolism via the effective inhibition of FabL hi addition, certain compounds are shown to be stable towards gamma radiation sterilization treatments, and are thus well-suited to the production of a sterile formulation for use in the treatment of illnesses caused by bacterial infections. |
申请公布号 |
WO2013190384(A1) |
申请公布日期 |
2013.12.27 |
申请号 |
WO2013IB01780 |
申请日期 |
2013.06.19 |
申请人 |
AFFINIUM PHARMACEUTICALS, INC. |
发明人 |
PARTRIDGE, JOHN, J.;COLUCCI, JOHN;GAREAU, YVES;THERIEN, MICHEL;ZAMBONI, ROBERT;HAFKIN, BARRY;MARFAT, ANTHONY;ZAGHDANE, HELMI |
分类号 |
C07F9/6561;A61K31/675;A61P31/04;C07F9/60 |
主分类号 |
C07F9/6561 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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