发明名称 |
OPTIMIZATION OF EXPRESSION AND PURIFICATION OF RECOMBINANT HUMAN MxA PROTEIN IN E. COLI |
摘要 |
<p>Full length MxA constructs and truncated MxA constructs produce human MxA protein in E. coli. The full length MxA and truncated MxA constructs are preferably E. coli codon-optimized to optimize the amount of protein made using the constructs. T5 or T7 promoters can each be used in combination with either the full length MxA or the truncated MxA constructs. In one preferred embodiment, the MxA protein produced by the full length MxA or truncated MxA constructs is used in a control prep or external control. In other preferred embodiments, the MxA protein is used as a therapeutic.</p> |
申请公布号 |
WO2013191906(A1) |
申请公布日期 |
2013.12.27 |
申请号 |
WO2013US44244 |
申请日期 |
2013.06.05 |
申请人 |
RAPID PATHOGEN SCREENING, INC. |
发明人 |
VANDINE, ROBERT W.;SAMBURSKY, ROBERT P.;BABU, UMA MAHESH;NAGATA, KYOSUKE |
分类号 |
C12N15/63;C12N15/12;C12Q1/00;C12Q1/68 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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