SIMULTANEOUS MEASUREMENT OF THROMBIN GENERATION AND CLOT STRENGTH IN PLASMA AND WHOLE BLOOD

摘要

The present invention relates to the simultaneous measurement of proteolylic enzyme generation and clot strength in plasma or whole blood or any appropriate biological sample derived from blood. The measurement method encompasses the use of a detectable substrate which comprises a moiety that can be released upon reaction with the targeted proteolytic enzyme, and means for measurement of an increase in viscosity of clot strength.