VALSARTAN-AMLODIPINE COMPOUND SOLID PREPARATION AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to a compound solid preparation and the preparation method therefor, and specifically relates to a valsartan-amlodipine compound solid preparation and the preparation method therefor. The valsartan-amlodipine compound solid preparation comprises valsartan particles and an amlodipine premix. The valsartan particles are prepared as follows: using an aqueous solution of ethanol as a wetting agent, and mixing valsartan and medicinal supplements; producing wet particles from the mixture; drying to produce valsartan particles. The amlodipine premix is prepared as follows: mixing amlodipine and medicinal supplements to produce the amlodipine premix. The valsartan-amlodipine compound solid preparation and the preparation method therefor of the present invention can prevent the mutual effect between the two main ingredients, amlodipine and valsartan. The preparation method is relatively simple and is suitable for large-scale industrial production.