发明名称 |
DETECTING AND TREATING DEMENTIA |
摘要 |
This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals. |
申请公布号 |
US2013345142(A1) |
申请公布日期 |
2013.12.26 |
申请号 |
US201313932727 |
申请日期 |
2013.07.01 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;VIB VZW;THE UNIVERSITY OF MANCHESTER;THE UNIVERSITY OF BRITISH COLUMBIA;UNIVERSITEIT ANTWERPEN |
发明人 |
HUTTON MICHAEL L.;BAKER MATTHEW CHARLES;GASS JENNIFER MAE;RADEMAKERS ROSA;ERIKSEN JASON;PICKERING-BROWN STUART M.;MACKENZIE IAN REID ALEXANDER;FELDMAN HOWARD;KUMAR-SINGH SAMIR;BROECKHOVEN CHRISTINE VAN;CRUTS MARC;CANNON ASHLEY DIANE |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|