| 发明名称 |
ARYL-SUBSTITUTED IMIDAZOLES |
| 摘要 |
The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| 申请公布号 |
US2013345237(A1) |
申请公布日期 |
2013.12.26 |
| 申请号 |
US201113876465 |
申请日期 |
2011.09.30 |
| 申请人 |
GUY R. KIPLIN;ZHANG YIQUN;YOUNG BRANDON;DYER MICHAEL;FINCH KRISTIN;BASHFORD DONALD;BHARATHAM NAGAKUMAR;KRIWACKI RICHARD;ROYAPPA GRACE;MIN LIE;MIN JAEKI;FERREIRA ANTHONY |
发明人 |
GUY R. KIPLIN;ZHANG YIQUN;YOUNG BRANDON;DYER MICHAEL;FINCH KRISTIN;BASHFORD DONALD;BHARATHAM NAGAKUMAR;KRIWACKI RICHARD;ROYAPPA GRACE;MIN LIE;MIN JAEKI;FERREIRA ANTHONY |
| 分类号 |
C07D403/06 |
主分类号 |
C07D403/06 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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