Method of reducing insulin resistance by administering a Hyaluronan-degrading enzyme

摘要

Provided herein are methods of reducing or ameliorating insulin resistant using a hyaluronan-degrading enzyme, and in particular a hyaluronan-degrading enzyme that is conjugated to a polymer. The methods also can be used to prevent or ameliorate diseases and conditions associated with insulin resistance, such as cardiovascular disease and type 2 diabetes.