METHOD OF PREPARING COMPOSITE GRANULE COMPRISING LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE AND RAPID RELEASE PREPARATION

摘要

The present invention provides a base for a dry-processed direct compression having excellent binding properties and disintegrating properties. Specifically, provided is a method for preparing composite granule formed by adding an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose wherein the degree of substitution of a hydroxypropoxy group is 5-16 wt%, polyvinyl alcohol, a first sugar or sugar alcohol, and water, and comprising at least a granulation process in which granulation of a second sugar or sugar alcohol is performed.