发明名称 |
SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (TDP1)- TOPOISOMERASE I (TOP1) INHIBITORS |
摘要 |
The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds. |
申请公布号 |
US2013345252(A1) |
申请公布日期 |
2013.12.26 |
申请号 |
US201313834652 |
申请日期 |
2013.03.15 |
申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
CUSHMAN MARK S.;NGUYEN TRUNG X.;CONDA-SHERIDAN MARTIN M. |
分类号 |
C07D221/18 |
主分类号 |
C07D221/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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