Monitor for particle injector

摘要

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

主权项

1. An assembly for delivering and monitoring delivery of particles to a material, comprising:
a delivery device configured to contain a particle and accelerate the particle in a desired direction; a volume through which the particle can pass; a spatial filter having mask features; a detector positioned to detect light emanating from the particle along a detection region within the volume, the detected light is modulated according to the mask features as the particle moves along the detection region, the detector configured to generate a time-varying signal in response to the detected light; an analyzer configured to receive the time-varying signal and determine a delivery success of the particle into the material based upon characteristics of the time-varying signal, the analyzer further configured to analyze one or more properties of the material; and control circuitry configured to vary one or more characteristics of delivery of the particle based upon one or more properties of the material and one or more characteristics of a reflected path of the particle.