Method for synthesizing laevo-p-hydroxyphenylglycine compound

摘要

Provided is a method for synthesizing a laevo-p-hydroxyphenylglycine compound, comprising: (1) subjecting an amine compound with a glyoxylic acid ester compound to a nucleophilic addition reaction; subjecting the product obtained in step (1) with a phenolic compound to a reaction in a manner similar to a Friedel-Crafts reaction in the presence of a chiral acid or a non-chiral acid, so as to generate the laevo-p-hydroxyphenylglycine compound. The method has advantages such as the final product having a high ee value, little pollution, and no need for treatments for resolution and racemisation.