发明名称 |
CHOLESTEROL ABSORPTION INHIBITOR (AZETIDINONE) AND OMEGA 3 FATTY ACIDS (EPA, DHA, DPA) FOR THE REDUCTION OF CHOLESTEROL AND FOR THE REDUCTION OF CARDIOVASCULAR EVENTS |
摘要 |
<p>A composition and a method of treatment utilizing a combination of lipid lowering cholesterol absorption inhibitors, e.g. azetidinones, with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight including a combination of Eicosapentaenoic acid (EPA), Docosapentaenoic acid (DP A) and Docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA represent about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition are taught. EPA + DHA are about 80% of the total formulation and about 89% of the total omega 3 fatty acid content of the composition. The formulation may further contain specific amounts of arachidonic acid (AA) and of omega-3 fatty acids having 18 carbon atoms, including one or more of stearidonic acid (SDA) and alpha-linolenic acid (ALA). The application further teaches methods of administering such combinations, and is directed towards unit dosages of such combinations for the reduction of risk factors for cardiovascular disease.</p> |
申请公布号 |
EP2675442(A1) |
申请公布日期 |
2013.12.25 |
申请号 |
EP20120705588 |
申请日期 |
2012.02.14 |
申请人 |
PIVOTAL THERAPEUTICS, INC. |
发明人 |
JACKOWSKI, GEORGE;MACSWEENEY, RACHELLE;SHAIKH, NISAR;YANTHA, JASON;SCHINI-KERTH, VALERIE |
分类号 |
A61K31/202;A61K31/397;A61K45/06;A61P9/00 |
主分类号 |
A61K31/202 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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