发明名称 |
Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
摘要 |
Increasing tolerance to butanol in yeast has been accomplished by decreasing activity of Pdr5p encoded by an endogenous PDR5 gene. A deletion mutation of the PDR5 gene led to improved growth yield in the presence of butanol. Yeast cells with reduced Pdr5p activity, or other multidrug resistance ATP-binding cassette transporter protein activity encoded by CDR1 or BFR1, and a butanol biosynthetic pathway may be used for improved butanol production. |
申请公布号 |
US8614085(B2) |
申请公布日期 |
2013.12.24 |
申请号 |
US20100711308 |
申请日期 |
2010.02.24 |
申请人 |
VAN DYK TINA K.;BUTAMAX(TM) ADVANCED BIOFUELS LLC |
发明人 |
VAN DYK TINA K. |
分类号 |
C12N1/15;C07H21/00;C07K14/00;C12N1/19;C12N9/00;C12N15/00;C12P7/16;C12P21/00 |
主分类号 |
C12N1/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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