| 摘要 |
The present invention relates to pharmaceutical uses of IL-2 and IL-2 antibody which are used for preventing or treating immune diseases caused by abnormality of immune responses and, more specifically, to a composition for preventing or treating immune diseases for elderly which includes IL-2 and IL-2 antibody. The IL-2 and IL-2 antibody according to the present invention can be effectively used as a pharmaceutical composition which can prevent or treat immune diseases in elderly such as autoimmune disease, inflammatory disease, and transplant rejection diseases which are caused by abnormal control of various immune responses by suppressing immune cells which are abnormally activated, suppressing activation of immune regulatory T cells (Treg) which controls inflammation responses, increasing expression of Foxp3 and STAT5, suppressing expression of Cebpb or IL-20, and having enhanced effects when IL-2 and IL-2 antibody are treated in elderly. Also the IL-2 and IL-2 antibody have no toxicity and side effects for medicine so that IL-2 and IL-2 antibody cab be used for inflammation diseases for long time, and have stable effects in vivo. |
