Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders

摘要

601866 Disclosed is an ethyne substituted phenyl compound of formula (A) where the substituents are as disclosed in the specification. Examples of a compounds of formula (A) are: -(3-((2,6-imethylphenyl)ethynyl)phenyl)propan-1-amine; 4-(3-(3-aminopropyl)phenyl)but-3-yn-1-ol; 1-(3-(3-aminopropyl)phenyl)-3-ethylpent-1-yn-3-ol; 1-((3-(3-aminopropyl)phenyl)ethynyl)-2,2,6,6-tetramethylcyclohexanol; 4-((3-(3-aminopropyl)phenyl)ethynyl)tetrahydro-2H-pyran-4-ol; 3-(3-(pyridin-4-ylethynyl)phenyl)propan-1-amine; 1-(3-(2-aminoethoxy)phenyl)-3-isopropyl-4-methylpent-1-yn-3-ol; and 1-((3-(1-aminopropan-2-yloxy)phenyl)ethynyl)cycloheptanol. Also disclosed are pharmaceutical compositions comprising a compound of formula (A) and the use of a compound of formula (A) in the manufacture of a medicament. The medicament is useful for modulating chromophore flux in a retinoid cycle; for the treatment of an ophthalmic disease or disorder in a subject and for the treatment of age-related macular degeneration or Stargardt's macular dystrophy.