发明名称 |
POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES |
摘要 |
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products. |
申请公布号 |
US2013337004(A1) |
申请公布日期 |
2013.12.19 |
申请号 |
US201313892163 |
申请日期 |
2013.05.10 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF |
发明人 |
LEE CHE-HUNG ROBERT;FRASCH CARL E. |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|