METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH THERAPEUTIC AGENT(S) IN PATIENTS WITH CONCURRENT NON-CNS CONDITION(S) OR DISORDERS CONTRAINDICATING SYSTEMIC ADMINISTRATION OF THE THERAPEUTIC AGENT(S)

摘要

Methods for delivering therapeutic agent(s) to the central nervous system to treat a first CNS-related disease and/or condition while avoiding systemic exposure for patients having a second concurrent non-CNS-related disease and/or condition wherein the presence of the second disease and/or condition contraindicates systemic administration of the therapeutic agent(s) and/or pharmaceutical compound to treat the first disease or condition. The present invention provides these advantages by applying the therapeutic agent(s) and/or pharmaceutical composition(s) to the upper third of the nasal cavity, thereby bypassing the blood-brain barrier and administering the therapeutic agent(s) and/or pharmaceutical compound(s) directly to the CNS. This administration method thus protects the mammalian patient, specifically the second non-CNS-related disease and/or condition, by minimizing systemic exposure to the therapeutic agent(s) and/or pharmaceutical compound(s) administered to treat the first disease and/or condition of the CNS.