BIOMARKER FOR DETERMINING THE SUITABILITY OF ANTI -TUMOUR NECROSIS FACTOR (ANTI-TNF) THERAPY IN THE TREATMENT OF AUTOIMMUNE DISEASES

摘要

The invention relates to methods of determining whether or not a patient is suitable for anti-tumour necrosis factor (anti-TNF) therapy. The invention also relates to methods of treating autoimmune diseases and methods of identifying whether or not a patient is at risk of developing multiple sclerosis (MS) or MS-like symptoms or whether or not a patient has MS. The invention further provides novel polypeptide TNF antagonists and related polynucleotides, expression vectors, host cells and antibodies.